Herbal Supplements for PMS: Evidence, Dosages, and Safe Use Guide

by Maverick Percy September 5, 2025 Supplements 20
Herbal Supplements for PMS: Evidence, Dosages, and Safe Use Guide

If PMS steals a week from you every month, you want real relief, not hype. Herbs get pitched as gentle, natural fixes. Some can help. Others don’t do much. I’ll show you what’s worth trying, how to use it safely, and when to switch lanes. I’m a dad who plans life in cycles because of the two little hurricanes in my house, Lawson and Phoebe-and I like simple, evidence‑backed answers you can act on today.

TL;DR

  • Best supported herbs: chasteberry (Vitex) for breast tenderness/irritability; saffron for mood; curcumin (turmeric extract) for overall PMS; ginkgo for breast pain/bloating; ginger for cramps.
  • What to skip: evening primrose oil has weak evidence for PMS. Use caution with St. John’s wort due to major interactions.
  • Safe‑use snapshot: try one product at a time for 2-3 cycles; standardize dose; check interactions (SSRIs, birth control, anticoagulants). Avoid in pregnancy unless cleared by your clinician.
  • Simple plan: track symptoms, pick one target symptom, trial one herb for 8-12 weeks, adjust based on measured change.
  • See a clinician if symptoms are severe, you suspect PMDD, or nothing changes after 3 cycles.

What actually works for PMS? The herbs with real evidence

The internet lumps vitamins, minerals, and plants together. Quick reset: this guide focuses on herbs and botanical extracts. Calcium and magnesium help many people, but they’re not herbs. When doctors’ groups discuss PMS, they put prescription options (SSRIs, certain birth control pills) first. Herbs sit in the "may help" column. That’s fine-let’s use them well.

Here’s the short list that has at least some randomized trial support or guideline acknowledgement (ACOG 2023 update, NICE guidance updates through 2024, and recent peer‑reviewed trials):

  • Chasteberry (Vitex agnus‑castus): Eases breast tenderness, irritability, headaches, and fluid retention in several trials. Typical standardized extract is 20 mg once daily (often labeled ZE 440). It likely works by nudging prolactin and dopamine pathways. It’s one of the few botanicals gynecology texts still mention for PMS.
  • Saffron (Crocus sativus): Small RCTs show 30 mg/day (15 mg twice daily) can lift mood and reduce anxiety/irritability in PMS and even PMDD. In early studies, saffron performed similarly to fluoxetine for mood improvements, though the trials were small.
  • Curcumin (high‑absorption turmeric extract): In multiple small trials, 500 mg twice daily from about 7 days before bleeding to 3 days after reduced total PMS scores. It targets inflammation and prostaglandins, which can drive pain and mood symptoms. Use a bioavailable form (with phospholipids or phytosome tech).
  • Ginkgo biloba: Doses of 120-240 mg/day (standardized to 24% flavone glycosides) reduced breast pain and fluid retention in some RCTs. Mood effects are mixed.
  • Ginger (Zingiber officinale): Best for cramps and nausea. 750-2000 mg/day of standardized extract taken at the start of pain often helps within hours to days. For classic PMS (mood, bloating, breast tenderness), evidence is thinner, but it’s a smart add‑on if period pain dominates.
  • Lemon balm (Melissa officinalis): A few small trials suggest 1200 mg/day can ease anxiety and improve sleep in PMS. It’s gentle and tends to be well‑tolerated.
  • St. John’s wort (Hypericum perforatum): Antidepressant effects are real, but this plant interacts with many medications and can reduce birth control effectiveness. Evidence for PMS/PMDD is mixed. If you’re already on SSRIs or hormonal contraception, this is usually a no‑go.
  • Chamomile: Tea or extract can calm and aid sleep. Helpful as a supportive habit. Data for PMS symptom scores are limited but risk is low.
  • Evening primrose oil: Popular, but controlled studies haven’t shown meaningful PMS benefits. If it’s going to work for you, it usually does so within 2 cycles. If not, move on.

That’s the rumor vs. reality tour. Now the fine print that will actually help you choose-and use-these well.

Herb Best for Evidence snapshot Typical dose When to take Notable risks/Interactions Evidence strength
Chasteberry (Vitex) Breast tenderness, irritability, headaches, fluid retention Multiple RCTs show symptom reduction; cited in gynecology texts and European monographs 20 mg/day of standardized extract (e.g., ZE 440) Daily, morning; allow 2-3 cycles Avoid in pregnancy; may affect dopamine/prolactin; caution with dopamine meds Moderate
Saffron Mood swings, anxiety, PMDD‑like symptoms Small RCTs show improved mood scores; preliminary head‑to‑head with SSRI in PMDD 30 mg/day (15 mg twice daily) of stigma extract Daily; benefits within 1-2 cycles High doses can cause uterine contractions; nausea, dizziness; avoid in pregnancy Moderate
Curcumin (turmeric extract) Global PMS symptoms, cramps, inflammation Small RCTs report lower total PMS scores 500 mg twice daily of bioavailable extract Luteal phase: ~day −7 to day +3 May thin blood at high doses; gallbladder issues; interacts with anticoagulants Low-Moderate
Ginkgo biloba Breast pain, swelling, bloating Some RCTs show benefit on mastalgia and physical PMS 120-240 mg/day (24% flavone glycosides) Daily starting mid‑cycle Bleeding risk with anticoagulants/antiplatelets; rare GI upset Low-Moderate
Ginger Cramps, nausea Strong for dysmenorrhea; limited PMS mood data 750-2000 mg/day extract; or 250 mg every 6-8 h At pain onset; can use daily late luteal if cramps predictably start Heartburn; bleeding risk with anticoagulants Moderate (for pain)
Lemon balm Anxiety, sleep issues Small trials show reduced PMS anxiety/sleep problems ~1200 mg/day extract; tea also useful Daily, evening dose may aid sleep Possible sedation; caution with sedatives Low
St. John’s wort Depressive symptoms Mixed for PMS/PMDD; good for depression 300 mg 3x/day (0.3% hypericin) or once‑daily 900 mg Daily; allow 2-4 weeks Major drug interactions; reduces OCP effectiveness; serotonin syndrome risk with SSRIs Low (for PMS)
Chamomile Tension, sleep Limited PMS trials; supportive for relaxation Tea/extract as needed Evening Ragweed allergy risk; theoretical bleeding risk Low
Evening primrose oil - Consistently underwhelming for PMS 1-3 g/day Daily Bleeding risk; interacts with certain psych meds Low

How to use herbs safely: dosing, timing, quality, and interactions

Quick rules that save time and headaches:

  • Pick one main symptom to target. Is it irritability? Breast pain? Cramps? One target makes your choice and measurement clear.
  • Change one thing at a time. If you stack three products, you won’t know what worked-or what caused side effects.
  • Standardize the dose. Look for exact milligrams and standardization (e.g., 20 mg chasteberry ZE 440; 30 mg saffron stigma extract; 24% ginkgo flavone glycosides).
  • Time it with your cycle. Many herbs work best when started mid‑cycle or during the luteal phase. Curcumin often shines when used from day −7 to day +3. Chasteberry and saffron are usually daily.
  • Give it at least two cycles. PMS rides hormonal rhythms; one week isn’t enough to judge.

Dosing cheat‑sheet:

  • Chasteberry: 20 mg standardized extract once daily, morning.
  • Saffron: 15 mg twice daily (total 30 mg). Take with food if you get nausea.
  • Curcumin: 500 mg twice daily of a high‑absorption extract, luteal phase use is common.
  • Ginkgo: 120-240 mg/day standardized, begin around ovulation.
  • Ginger: 250-500 mg every 6-8 hours as needed for cramps (up to 2000 mg/day).
  • Lemon balm: 300-600 mg twice daily; tea in the evening is fine.

Safety and interactions you should actually check:

  • Pregnancy and trying to conceive: avoid chasteberry, saffron, and high‑dose curcumin unless your clinician okays it. Several herbs can affect uterine tone or hormones.
  • Hormonal contraception: St. John’s wort can lower pill effectiveness. Most other herbs listed don’t reliably reduce pill levels, but data are limited-ask if you’re unsure.
  • Mood meds: If you’re on SSRIs/SNRIs, skip St. John’s wort. Saffron has been combined with SSRIs in research, but do this only with supervision.
  • Bleeding risk: Ginkgo, ginger, curcumin, and evening primrose oil can increase bleeding, especially with anticoagulants or high‑dose NSAIDs.
  • Liver/thyroid: Rare liver injury has been reported with ashwagandha (not recommended here). Lemon balm may add sedation. Curcumin can bother the gallbladder.
  • Allergies: Chamomile is a ragweed cousin. If you’re very allergic in late summer, start small.

How to buy quality without a chemistry degree:

  • Look for third‑party testing seals: USP Verified, NSF, or an up‑to‑date Certificate of Analysis from the brand.
  • Avoid “proprietary blends.” You need exact milligrams to dose correctly.
  • Pick single‑ingredient products when you’re testing. Blend later if you find a winner.
  • Choose forms used in studies: chasteberry ZE 440; saffron stigma extract at 30 mg; ginkgo at 24% flavone glycosides; curcumin with absorption tech (phytosome/meriva or similar).
  • Store like food: cool, dry, away from sunlight. Pitch anything that smells off or clumps.
A simple 12‑week plan to test an herbal approach

A simple 12‑week plan to test an herbal approach

I like plans you can follow on a calendar, not just in theory. Here’s a practical way to learn what actually moves your symptoms.

  1. Baseline (week 0): Name your top 1-2 symptoms. Download a tracker or use the free Daily Record of Severity of Problems (DRSP) template. Rate symptoms daily for one full cycle with no changes. This sets your starting line.
  2. Pick the first herb (week 1):
    • If mood/irritability dominates: start saffron or chasteberry.
    • If breast tenderness and bloating dominate: start chasteberry or ginkgo.
    • If cramps dominate: start ginger, and consider luteal‑phase curcumin.
  3. Set a precise dose and schedule: Write it down. Keep it boring and consistent.
  4. Run the trial for 2 cycles: No other new supplements. Track daily. Note any side effects.
  5. Check your data (end of cycle 2): Look for a 30% or better drop in your main symptom score. If you hit it and side effects are minimal, continue. If not, switch to your second choice.
  6. Add‑on if needed (cycle 3): If you have a partial win (say cramps much better but mood not), you can add a second herb that targets the remaining symptom. Example: keep ginger, add saffron.
  7. Layer in proven non‑herbal basics: Calcium (1000-1200 mg/day from food plus supplements if needed), regular exercise, 7-9 hours sleep, light therapy for winter blues, CBT skills if ruminations spiral. These have stronger guideline support than most botanicals.
  8. Reassess at week 12: If you’ve tried two targeted herbs across three cycles with no meaningful change, it’s time to talk about SSRIs (continuous or luteal‑phase), a drospirenone‑containing contraceptive, or CBT-tools with bigger effects for many people.

Pro tips from the clinic side:

  • Dose timing can matter: take curcumin with fat; take chasteberry in the morning; split ginkgo into two doses if you get nausea.
  • Don’t chase every symptom at once. Fix the loudest one first.
  • Cycles shift with stress, sleep, and travel. If your month was chaos, extend the trial one more cycle before judging.
  • Write a one‑sentence rule for yourself: “If no 30% improvement by the end of my second cycle, I switch.” It prevents supplement drift.

Trade‑offs and when to choose standard treatments

Herbs can help. They typically deliver small‑to‑moderate relief with fewer side effects than many meds. Prescription options often work faster and stronger, especially for PMDD. Here’s how I frame it when someone is deciding:

  • If your main symptoms are mild to moderate and you prefer a low‑risk start, herbs are reasonable.
  • If your symptoms crush work, school, or relationships-or if you see sudden mood drops, rage spikes, or suicidal thoughts-go straight to established treatments and therapy. You can still keep ginger for cramps.
  • SSRIs (fluoxetine, sertraline) can be taken just during the luteal phase and often help within the first cycle. A drospirenone/ethinyl estradiol pill can steady hormones and reduce PMS for many people.

Red flags-don’t wait on these:

  • Thoughts of harming yourself or others.
  • New panic attacks or prolonged depressive episodes tied to your cycle (think PMDD).
  • Severe pain unresponsive to usual meds, fainting, fever, or signs of anemia (extremely heavy bleeding).
  • Unexpected bleeding patterns if you’re on hormonal birth control.

How to talk with your clinician without losing the thread:

  • Bring your symptom tracker. Two cycles of data beats vague descriptions.
  • Say what you tried, the exact dose, and how it changed your scores.
  • Ask about a short luteal‑phase SSRI trial or a pill with drospirenone if mood is the main problem.
  • Ask if your plan to keep a helpful herb (like ginger for cramps) fits safely with prescriptions.
Checklists, quick answers, and troubleshooting

Checklists, quick answers, and troubleshooting

Shopping checklist (print or screenshot):

  • Clear ingredient and exact milligram amount.
  • Standardized extract listed (e.g., 24% ginkgo flavone glycosides; 30 mg saffron stigma).
  • Third‑party tested (USP, NSF, or a recent Certificate of Analysis).
  • No proprietary blends for your first trial.
  • Lot number and expiration date present.

Safety checklist before you start:

  • Pregnant, nursing, or TTC? Get a green light first.
  • On SSRIs, SNRIs, mood stabilizers, blood thinners, or birth control? Double‑check interactions.
  • Personal or family history of bleeding disorders, liver disease, or gallbladder disease? Start low and report any issues.
  • Set a stop date if there’s no benefit (after 2-3 cycles).

Mini‑FAQ

  • Can I combine herbs? Yes, after you find one clear winner. Common pairs: saffron + curcumin for mood plus pain; chasteberry + ginkgo for breast tenderness and bloating. Add one at a time.
  • Do herbs mess with birth control? St. John’s wort can reduce pill effectiveness. Most others here don’t have strong evidence of doing so, but data are incomplete. If pregnancy prevention is critical, confirm with your clinician.
  • When should I start each month? Daily for chasteberry and saffron. Luteal‑phase use for curcumin (about a week before bleeding). Ginkgo from mid‑cycle. Ginger when cramps start.
  • How long until I feel something? Pain relief (ginger) can happen the same day. Mood and tender‑breast relief (saffron, chasteberry, ginkgo) often needs 1-2 cycles.
  • Can teens use these? Many herbs are used by teens, but dosing and interactions still matter. Track carefully and loop in a clinician, especially if school performance or mood is slipping.
  • Tea or capsules? Tea can help with soothing herbs like chamomile or lemon balm. For measurable PMS changes, standardized capsules or tablets are more reliable.
  • Will chasteberry affect fertility? It can affect prolactin and cycle regularity. If you’re trying to conceive or have irregular cycles, talk with a clinician first.
  • What about ashwagandha or rhodiola? They reduce stress for some people, but PMS‑specific data are limited. If stress is your main trigger and you’re not pregnant or on interacting meds, discuss a short trial with your clinician.

Troubleshooting by scenario:

  • Mood is the bully; pain is minor: start saffron. If partial relief, add luteal‑phase curcumin. If still rough by cycle 3, consider a luteal‑phase SSRI.
  • Breast tenderness and bloat wreck the week: start chasteberry. If tenderness remains high after two cycles, add ginkgo.
  • Cramps overshadow everything: start ginger on day 1 of pain and curcumin late luteal. If pain still limits you, ask about NSAID timing/dose and evaluate for endometriosis.
  • On an SSRI already: skip St. John’s wort. You can still use ginger, curcumin (with approval), and possibly saffron; coordinate with your prescriber.
  • On a blood thinner: avoid ginkgo, high‑dose ginger, and high‑dose curcumin unless your prescriber okays it and monitors you.

Last thing: track and decide. If your scores drop by 30% or more and you’re functioning better, you found something that matters. If not, don’t keep buying bottles hoping the label will suddenly work. Switch strategies. That’s the power move with herbal supplements for PMS.

Sources I trust when weighing this stuff: ACOG guidance on PMS/PMDD (updated through 2023), NICE guidance on menstrual conditions (latest updates through 2024), Cochrane reviews on Vitex and PMS, and NIH Office of Dietary Supplements fact sheets for each herb. They’re dry, but they keep me honest.

Author: Maverick Percy
Maverick Percy
Hi, I'm Finnegan Radcliffe, a pharmaceutical expert with years of experience in the industry. My passion for understanding medications and diseases drives me to constantly research and write about the latest advancements, including discovery in supplement fields. I believe that sharing accurate information is vital in improving healthcare outcomes for everyone. Through my writing, I strive to provide easy-to-understand insights into medications and how they combat various diseases. My goal is to educate and empower individuals to make informed decisions about their health.

20 Comments

  • Erik Redli said:
    September 5, 2025 AT 02:20

    All this hype about herbal PMS fixes is just marketing fluff. People think Vitex is a miracle, but the data barely beats placebo. If you want real relief, stop chasing herbs and get a proper hormonal eval. The guide wastes time.

  • Jennyfer Collin said:
    September 5, 2025 AT 07:53

    It is incumbent upon us to scrutinize the provenance of these botanical extracts, lest the unseen cabal of supplement manufacturers manipulate our endocrine equilibrium. The systematic omission of adverse‑event disclosures in many trials suggests an orchestrated concealment. One must therefore approach any recommendation with a calibrated skepticism, recognizing that profit motives often eclipse patient safety. The inclusion of standardization metrics, for instance ZE‑440, is but a veneer masking deeper uncertainties. Consequently, I advise a vigilant appraisal of each product label, cross‑referencing with independent pharmacovigilance databases 🧐.

  • Tim Waghorn said:
    September 5, 2025 AT 13:26

    The presented dosage schema aligns with extant pharmacognostic literature wherein chasteberry extracts are standardized to 20 mg of agnus‑castus per day. Nonetheless, the temporal parameters for luteal‑phase initiation warrant explicit delineation to mitigate inter‑individual variability. Moreover, the interaction matrix enumerated for curcumin implicates cytochrome‑P450 substrates, necessitating clinician oversight. It would be prudent to append a decision‑tree algorithm to the guide for rapid risk stratification.

  • Brady Johnson said:
    September 5, 2025 AT 19:00

    When I dissect the data pool, the signal‑to‑noise ratio for saffron’s mood‑lifting effect appears disturbingly thin, bordering on statistical mirage. The clinical community’s enthusiasm seems fueled by a cascade of anecdotal hype rather than robust efficacy. In the shadow of this overstatement, patients are left navigating a labyrinth of half‑filled promises. The danger lies not in the herb itself but in the vacuum it creates for evidence‑based treatment.

  • Jay Campbell said:
    September 6, 2025 AT 00:33

    I appreciate the thoroughness of this guide; it gives a solid starting point for anyone wanting to try herbs responsibly.

  • Laura Hibbard said:
    September 6, 2025 AT 02:46

    Sure, because after a day of negotiating bedtime treaties with two toddlers, the last thing anyone needs is a spreadsheet of botanical milligrams. Yet, oddly enough, that spreadsheet might actually keep the chaos at bay. It’s a strange comfort to know the same routine that tracks tantrums can also track hormone swings. So, if you’re already counting down to bedtime, why not count down the herb doses too?

  • Rachel Zack said:
    September 6, 2025 AT 08:20

    People should stop treating supplements like candy; they are not a free‑for‑all buffet for anyone who feels a twinge. It is morally indefinately wrong to push unproven products on vulnerable women. The guide does a decent job, but we must remember that no herb can replace responsible medical care. Its a matter of ethical responsibility, not just personal preference.

  • Lori Brown said:
    September 6, 2025 AT 10:33

    Exactly! 🙌 Let’s empower ourselves with knowledge while staying grounded in reality. You can try a vetted chasteberry product and still keep your doctor in the loop. This balanced approach makes the journey less scary and more hopeful. Keep shining! 🌟

  • Jacqui Bryant said:
    September 6, 2025 AT 16:06

    If you’re feeling crampy, ginger can help fast. Just take the recommended dose when the pain starts. It’s easy and cheap. Hope it works for you!

  • Paul Luxford said:
    September 6, 2025 AT 21:40

    The tables summarizing dose and evidence are particularly useful; they condense a lot of information into a digestible format. I would suggest adding a column for typical onset of effect, as clinicians often need to set patient expectations. Overall, the guide is a commendable effort toward evidence‑based supplementation.

  • Nic Floyd said:
    September 7, 2025 AT 03:13

    From a pharmacokinetic standpoint the bioavailability of curcumin is enhanced by phospholipid complexation (e.g. Meriva) facilitating hepatic first‑pass metabolism bypass 🚀 this results in higher plasma Cmax and prolonged t½ which translates to clinically meaningful anti‑inflammatory activity across the luteal phase especially when synchronized with dietary fat intake 🍽️ the synergy with ginkgo's vasodilatory flavonoids further augments peripheral tissue perfusion thereby potentially ameliorating mastalgia

  • Johnae Council said:
    September 7, 2025 AT 08:46

    Look, the whole “natural = safe” mantra is nonsense. I've seen people keel over because they over‑dose ginger or mix ginkgo with blood thinners. The guide mentions it, but most readers skim. So, be real: read the fine print or you might end up in the ER.

  • Manoj Kumar said:
    September 7, 2025 AT 14:20

    Ah, the eternal quest for balance: we chase herbs like philosophers chasing meaning, only to discover the universe laughs at our spreadsheets. Still, there’s something beautifully earnest about measuring mood swings with a capsule count. If the herbs don’t work, at least you’ve practiced discipline-a virtue in any school of thought. Keep the sarcasm as your compass, but let the data be your map.

  • Hershel Lilly said:
    September 7, 2025 AT 19:53

    I find the interplay between serotonin modulation by saffron and dopamine pathways of chasteberry fascinating, especially when considering adjunctive therapy with SSRIs. The guide could elaborate on how to sequence these interventions to avoid serotonergic overload. Nevertheless, the recommendation to start with a single herb before layering is sound and reflects prudent clinical reasoning. This systematic approach respects both efficacy and safety.

  • Carla Smalls said:
    September 8, 2025 AT 01:26

    You’ve laid out a clear roadmap, and that’s half the battle won. Remember, consistency is key-track those scores like a pro and celebrate small wins. If one herb falls short, the plan lets you pivot without losing momentum. Keep your chin up; you’ve got this!

  • Monika Pardon said:
    September 8, 2025 AT 07:00

    In the grand tapestry of pharmaceutical intrigue, one might suspect that the very mention of ‘standardized extracts’ is a covert nod to the shadowy cabal steering our endocrine destiny. Yet, here we are, casually sipping tea while the elite draft policies behind closed doors. The guide, dripping with earnest advice, somehow sidesteps the obvious puppet‑masters. One can only grin wryly at the paradox.

  • Rhea Lesandra said:
    September 8, 2025 AT 12:33

    First, thank you for sharing such a thorough guide.

    The depth of information regarding each botanical, from chasteberry's dopaminergic influence to the nuanced timing of luteal‑phase curcumin administration, demonstrates a commendable commitment to marrying empirical evidence with practical user guidance, which is rarely seen in the often superficial landscape of online supplement discussions.

    The table format is a visual boon.

    By juxtaposing dosage, target symptoms, and interaction warnings side by side, readers can rapidly assimilate complex data without having to sift through dense paragraphs of prose, thereby reducing cognitive overload and promoting informed decision‑making.

    The safety checklist is essential.

    Including prompts about pregnancy status, anticoagulant use, and potential hepatic concerns underscores an ethical responsibility to safeguard vulnerable populations, reflecting a level of diligence that should be standard practice across all health‑related content.

    The 12‑week trial plan is realistic.

    Setting a timeline of two to three cycles before evaluating efficacy respects the physiological rhythm of the menstrual cycle and avoids premature dismissal of interventions that may require a steady state to manifest measurable benefits, a nuance that many quick‑fix articles overlook.

    Personalized symptom tracking is empowering.

    Employing tools like the DRSP not only quantifies subjective experiences but also creates a data set that can be shared with clinicians, bridging the gap between self‑care and professional oversight.

    The guide wisely highlights when to seek medical help.

    By explicitly stating red‑flag symptoms such as severe mood disturbances or uncontrolled bleeding, it equips readers with critical thresholds that can prevent escalation into more serious health crises.

    Inclusion of non‑herbal basics rounds out the approach.

    Acknowledging the foundational role of calcium, magnesium, exercise, and sleep ensures that herbal supplementation is not viewed in isolation but as part of a holistic lifestyle strategy.

    Overall, this resource stands as a model of evidence‑based, user‑friendly health education.

  • Kasey Marshall said:
    September 8, 2025 AT 14:46

    Great points Kasey adds that simple tracking can be done with a phone app it makes data collection painless and consistent keep it up

  • Dave Sykes said:
    September 8, 2025 AT 20:20

    Stick to the plan and you’ll see progress.

  • Erin Leach said:
    September 8, 2025 AT 22:33

    I understand how hard it can be to stay motivated, especially when symptoms feel overwhelming, but having a clear routine can really make a difference in how you feel day to day.

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