Gels: What They Are and How to Use Them Safely

Gels are a common way to deliver medicine through the skin or mouth. They come in two main forms: topical gels for skin problems and transdermal gels that let drugs enter your bloodstream. Examples you might know: diclofenac gel for pain, metronidazole gel for rosacea, lidocaine gel for numbing, and testosterone or nicotine gels that act systemically. Knowing the basics keeps you safer and helps the medicine work better.

How to apply gels the right way

Start with clean, dry skin. Apply the exact amount your prescriber or the label tells you — more is not better and can increase side effects. Spread thinly unless a thicker layer is recommended. Some gels need to be rubbed in; others are left to dry. If the instructions say “avoid washing” for a few hours, follow them so the drug can absorb. Always wash your hands after applying a gel unless your hands need treatment. Keep children and pets away from treated areas until the gel is fully absorbed.

If you use a transdermal hormone or nicotine gel, rotate sites to lower skin irritation and avoid applying to broken or irritated skin. Covering the area with tight clothing can increase absorption; check your leaflet to see whether that’s OK. Don’t shower, bathe, or swim right after application if the manufacturer warns against it.

Storage, safety, and buying tips

Store gels as the label directs. Most stay fine at room temperature away from heat and sunlight, but a few need refrigeration—so check. Throw away expired or contaminated tubes. Never share prescription gels with others; a dose that’s safe for you can harm someone else.

Buying gels online? Use licensed pharmacies, read reviews, and avoid offers that seem too cheap. For prescription gels, a legitimate pharmacy will ask for a prescription. Compounded gels are an option for specific needs, but only use reputable compounding pharmacies and ask about sterility and testing.

Be aware of side effects and interactions. Local irritation, redness, or itching are common with topical gels. More serious reactions, like widespread rash or breathing trouble, need urgent care. Some topical steroids or hormone gels can cause systemic effects if used long-term or over large areas. Tell your prescriber about other meds and supplements you use, and mention pregnancy or breastfeeding.

If a gel isn’t working or causes irritation, don’t keep squeezing more on. Call your pharmacist or doctor — small changes in dose, frequency, or formulation often fix the problem. When you understand the product, follow instructions closely, and use trusted sellers, gels are a safe, effective way to treat many conditions at home.