Vortioxetine (Trintellix): What It Is and How to Use It

Vortioxetine is an antidepressant doctors often prescribe for major depressive disorder. It’s sometimes sold under the brand Trintellix. People choose it because it works on several serotonin targets, which can help mood and, in some cases, thinking or focus that’s affected by depression.

Most people take vortioxetine once a day. The usual starting dose is 10 mg daily. Your prescriber may lower the dose to 5 mg if you’re sensitive to side effects, or increase it to 20 mg if 10 mg doesn’t help enough. If you take strong CYP2D6 inhibitors (drugs like fluoxetine or bupropion) or you’re a known CYP2D6 poor metabolizer, your doctor will likely limit the vortioxetine dose — mention any other meds you use.

Common Side Effects and Safety Notes

Nausea is the most common side effect and often improves after the first few weeks. Other side effects can include constipation, dizziness, dry mouth, sweating, and sleep changes. Sexual side effects may occur but some people report fewer sexual problems than with older SSRIs.

Watch for signs of serotonin syndrome if you combine vortioxetine with other serotonergic medicines (SSRIs, SNRIs, triptans, certain migraine drugs, or some herbal supplements like St. John's wort). Symptoms to know: high fever, confusion, fast heartbeat, severe muscle stiffness, or sudden changes in balance. Seek immediate care if those happen.

If you take blood thinners or NSAIDs, tell your prescriber — antidepressants can increase bleeding risk. If you’re pregnant, breastfeeding, or have serious liver problems, talk with your doctor before starting vortioxetine. Don’t stop it abruptly; your clinician will advise how to taper to avoid withdrawal symptoms.

Practical Tips for Taking and Buying Vortioxetine

Take vortioxetine at the same time every day, with or without food. If you miss a dose, take it when you remember unless it’s near the next dose — don’t double up. Give a new antidepressant 4–6 weeks to see noticeable benefits, and report any worsening mood, suicidal thoughts, or unusual behavior right away.

Vortioxetine requires a prescription in most countries. If you buy online, use licensed pharmacies only. Check for a physical address and pharmacist contact, verify site credentials, and avoid offers that don’t ask for a prescription. Cheap, no-prescription options are risky: you might get the wrong drug, the wrong dose, or a counterfeit product. Ask your pharmacist about shipping time and how the medication is stored during transit.

Have questions or side effects? Talk to your prescriber or pharmacist. They can help adjust dose, check for interactions, and make sure vortioxetine fits your overall treatment plan.