Foods to Avoid with MAOIs: What You Must Skip to Stay Safe

When you're taking MAOIs, a class of antidepressants that work by blocking monoamine oxidase enzymes to boost mood-regulating brain chemicals. Also known as monoamine oxidase inhibitors, they can be life-changing for people who haven’t responded to other antidepressants—but they come with a strict, non-negotiable rule: avoid certain foods. The biggest danger? A sudden, dangerous rise in blood pressure caused by tyramine, a naturally occurring compound found in aged, fermented, or spoiled foods. Your body normally breaks down tyramine with enzymes that MAOIs shut down. When tyramine builds up, it triggers a surge of adrenaline that can lead to stroke, heart attack, or even death.

This isn’t just a vague warning. It’s a clear list of foods you need to skip. Aged cheeses, like cheddar, blue cheese, parmesan, and brie are high-risk. So are cured or smoked meats, including salami, pepperoni, summer sausage, and pickled herring. Even fermented soy products, like soy sauce, miso, and tempeh can be dangerous. Don’t forget tap beer and some wines—especially those that are unpasteurized or aged. And yes, that leftover bolognese in the fridge? If it’s been sitting more than a day or two, it’s not worth the risk.

It’s not just about what’s on the plate. Some over-the-counter cough syrups, herbal supplements like St. John’s Wort, and even certain decongestants can interact with MAOIs and cause the same deadly spike. That’s why knowing your meds and your meals is part of your treatment plan. You’re not being overly cautious—you’re protecting your heart, your brain, and your life. The good news? Once you learn the list, it becomes second nature. Many people on MAOIs report feeling better than ever once they get past the initial adjustment—because they finally found a treatment that works, and they’re eating safely while doing it.

Below, you’ll find real, practical advice pulled from patient experiences and clinical guidance. You’ll see what people actually eat on MAOIs, how they plan meals, and what mistakes to avoid. No fluff. No fearmongering. Just clear, actionable info to help you stay in control—and safe.